Effect Of Antioxidant Substances In Experimental Alloxan-Induced Diabetes
Keywords:
Diabetes mellitus, antioxidants, sodium dichloroacetate, glutathioneAbstract
The aim of this study was to investigate the effects of antioxidant substances on carbohydrate and lipid metabolism in experimental alloxan-induced diabetes mellitus. The experiment was carried out on 60 male white rats weighing 180–200 g. Diabetes mellitus was induced by intraperitoneal injection of alloxan monohydrate. The development of diabetes was accompanied by severe hyperglycemia and disturbances in lipid metabolism. Among the tested substances, quercetin and sodium dichloroacetate demonstrated significant hypoglycemic and hypolipidemic effects, indicating their potential therapeutic value in the correction of metabolic disorders associated with diabetes mellitus.
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