Improving Methods For Diagnosing Endocrine Infertility
Keywords:
Infertility, endocrine infertility, pituitary dysfunctionAbstract
Endocrine infertility is one of the most common forms, the origin of which is directly related to a decrease in ovarian reserve, hormonal imbalance, metabolic changes, and immunological factors. Functional disorders in the endocrine system disrupt the maturation process of egg cells, cause ovulation to fail, and this causes serious problems in restoring fertility in women
Objective: In the early diagnosis and prognosis of women with endocrine infertility, the level of expression of epigenetic markers Let-7b-5p, miR-223-3p, and miR-320a was studied, and their pathogenetic relationship with clinical, hormonal, and echographic indicators was proven.
Results: This study is distinguished by the fact that it covers biomarker-based approaches in the diagnosis of women with infertility of endocrine genesis, and this algorithm is important for restoring fertility and improving the resultsThe introduction of differentiated, pathogenetically based, and individualized approaches to cases of infertility of endocrine origin not only increased clinical effectiveness, but also provided a wide range of social and economic benefits. According to the results of the study, in women with infertility against the background of hyperprolactinemia, hypothyroidism, and ovarian dysfunction, against the background of targeted therapy (cabergoline, tyramine, ovariamine), the frequency of ovulation and pregnancy significantly increased (56.7-66.7% and 33.3-40.0%, respectively).
Conclusions:The introduction of differentiated, pathogenetically based, and individualized approaches to cases of infertility of endocrine origin not only increased clinical effectiveness, but also provided a wide range of social and economic benefits.
this study is distinguished by the fact that the diagnosis of women with infertility of endocrine genesis includes individual, biomarker-based approaches, which is important for the restoration of fertility and improvement of results.
References
Shukurov F.I., Mamajanova D.M., Sattarova K.A., Yuldasheva N.Z. Evaluation of the effectiveness of using Belara in the adjuvant therapy of polycystic ovary syndrome after endosurgical treatment. Experimental and Clinical Pharmacology. 2022;85 (8): 14-6.
Sherbakova E.S., Lusevich A.I. Endocrine infertility. Alley of Science. 2020; 2 (6): 403
IVF in gynecological and endocrine diseases / Edited by T.A. Nazarenko. M.: GEOTAR-Media, 2016. 176 p.
Ach T, Dhaffar R, Ben Abdessalem F, Saafi W, Halloul I, ElFekih H, Saad G, Hasni Y. Subclinical Hypothyroidism in Polycystic Ovary Syndrome: Prevalence and Impact on Metabolic and Cardiovascular risk. Clin Med Insights Endocrinol Diabetes. 2025 Jun 3;18:11795514251343678.
Al–Ruthia YS, Al-Mandeel H, AlSanawi H. Ovulation induction by metformin among obese versus non-obese women with polycystic ovary syndrome. Saudi Pharm J. 2017;25:795–800.
Andersen M, Glintborg D. Metabolic Syndrome in Hyperprolactinemia. Front Horm Res. 2018;49:29-47.
Andreeva P. Thyroid gland and fertility. Akush Ginekol (Sofiia). 2014;53(7):18–23.
Azziz R. PCOS in 2015: new insights into the genetics of polycystic ovary syndrome. Nat Rev Endocrinol. 2015;12(2):74–5.
Aykanat Yurtsever B, Yurtsever C. Association between vitamin D levels and thyroid function tests in euthyroid women with obesity. Sci Prog. 2025 Apr-Jun;108(2):368504251347697.
Ban M, Jiao J, Zhou J, Cui L, Wang H, Chen ZJ. Association of age at menarche and different causes of infertility: a retrospective study of 7634 women undergoing assisted reproductive technology. J Ovarian Res. 2025 Feb 26;18(1):40.
Bucci I, Giuliani C, Di Dalmazi G, Formoso G, Napolitano G. Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technology Outcome. Front Endocrinol (Lausanne). 2022 May 26;13:768363.
Barut MU, Agacayak E, Bozkurt M, et al. There is a Positive Correlation Between Socioeconomic Status and Ovarian Reserve in Women of Reproductive Age. Med Sci Monit. 2016;22:4386-4392.
Bellver J, Rodriguez-Tabernero L, Robles A, et al. Polycystic ovary syndrome throughout a woman’s life. J Assist Reprod Genet. 2018;35(1):25–39.
Björvang RD, Damdimopoulou P. Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women. Ups J Med Sci. 2020;125(2):85–94.
Bo W, Zhang N, Wang L, Guo Y, Wu H. Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility. BMC Pregnancy Childbirth. 2021 Jan 6;21(1):16.
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