Sensitivity To Glucocorticoids In Synovial Fluid In Rheumatoid Arthritis: The Key To Effective Therapy
Keywords:
Rheumatoid arthritis, synovial fluid, glucocorticoid sensitivityAbstract
The aim of the study was to study the nature of GCR in the synovial fluid (SF) in rheumatoid arthritis (RA).
Materials and methods. SF sampling was performed under aseptic con-ditions by puncture of the knee joint in 31 patients with RA. SF was studied immu- nopharmacologically for sensitivity to six systemic glucocorticoids – betamethasone, dexamethasone, triamcinolone, methylprednisolone, predni-sone, and hydrocortisone using an original proprietary technique.
Results. The largest number of very highly sensitive drugs are hydrocor-tisone and triamcinolone, followed by betamethasone, followed by dexame-thasone and methylprednisolone, and prednisone. Among the highly sensitive drugs, betamethasone and triamcinolone came first, hydrocortisone came sec-ond, and prednisone and dexamethasone came last. Prednisone and dexame-thasone account for the largest number of low-sensitivity patients, followed by the same distribution of betamethasone, methylprednisolone, and triamcino-lone. Among the very low-sensitivity cases, methylprednisolone account for the largest number of cases, followed by prednisone and dexamethasone, fol-lowed by triamcinolone and betamethasone. It should be noted that different degrees of sensitivity to drugs were detected in the same patient in SF.
Conclusion. The data obtained should be taken into account when ad-ministering GK intra-articularly in patients with synovitis, especially recurrent synovitis in patients with RA.
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