Physiological Foundations Of The Development Of Metabolic Syndrome In The Body
Keywords:
Insulin, arterial hypertension, triglycerides, glucoseAbstract
The prevalence of metabolic syndrome is increasing year by year, and this is a serious threat to global health. Abdominal fat accumulation, including visceral fat mass, increases inflammatory mediators and increases metabolic dysfunction through adipokine imbalance. Some variables play an important role in the probability of developing heart disease in a person. These variables are called risk factors. Some of these risk factors for heart disease accumulate in certain individuals. Such a cluster of risk factors is called metabolic syndrome.
References
Djurayeva Ra’no Xayrulloyevna Metabolic syndrome: etiology, pathogenesis, clinic alfeatures, prevention, andtreatment. American Academic Publisher. International Journal of medical sciences. ISSN Number: 2692-5206 Volume 5. No 12. December, 2025.
Alberti, K.G.M.M., Zimmet, P., & Shaw, J. (2005). The metabolic syndrome—anewworldwide definition. The Lancet, 366(9491), 1059–1062.
S.A.Saidov, S.B.Azimova, A.B.Bekmuratova, J.A.Mirsultanov Metabolik sindrom patogenezining zamonaviy tushunchalari. Academic Research in Educational Sciences ISSN: 2181-1385 Volume 5 | Issue 5 | 2024
Welty F.K., Alfaddagh A., Elajami T.K. Targeting inflammation in metabolic syndrome // Transl. Res. – 2016. – Vol. 167, No. 1. – P. 257–280. – DOI: 10.1016/j.trsl.2015.06.017.
Barber T.M., Kyrou I., Randeva H.S., Weickert M.O. Mechanisms of insulin resistance at the crossroad of obesity with associated metabolic abnormalities and cognitive dysfunction // Int. J. Mol. Sci. – 2021. – Vol. 22, No. 2. – 546. – DOI: 10.3390/ijms 22020546.
Palmnäs M.S.A., Kopciuk K., Shaykhutdinov R.A., et al. Serum metabolomics of activity energy expenditure and its relation to metabolic syndrome and obesity // Sci. Rep. – 2018. – Vol. 8. – 3308. – DOI: 10.1038/s41598-018-21585-6.
Hearris M.A., Owens D.J., Strauss J.A., et al. Graded reductions in pre-exercise glycogen concentration do not augment exercise-induced nuclear AMPK and PGC-1α protein content in human muscle // Exp. Physiol. – 2020. – Vol. 105. – P. 1882–1894. – DOI: 10.1113/EP088866.
Goodpaster B.H., Sparks L.M. Metabolic flexibility in health and disease // Cell Metab. – 2017. – Vol. 25, No. 5. – P. 1027–1036. – DOI: 10.1016/j.cmet.2017.04.015.
Yaribeygi H., Maleki M., Sathyapalan T., Jamialahmadi T., Sahebkar A. Pathophysiology of physical inactivity-dependent insulin resistance: a theoretical mechanistic review emphasizing clinical evidence // J. Diabetes Res. – 2021. – Article ID 7796727. – 12 p. – DOI: 10.1155/2021/7796727.
D.F.Sultonova Functional Adaptation Effectiveness of Students with Different Levels of Preparedness for Training During the Adaptation Process. International Journal of Genetic Engineering 2024, 12(2): 17-20
DOI: 10.5923/j.ijge.20241202.02
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